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Abnormal RNA processing and altered expression of serin-rich proteins in minimal-change nephrotic syndrome.

Authors :
Grimbert P
Audard V
Valanciute A
Pawlak A
Lang P
Guellaƫn G
Sahali D
Source :
Pediatric research [Pediatr Res] 2005 Jan; Vol. 57 (1), pp. 133-7. Date of Electronic Publication: 2004 Nov 05.
Publication Year :
2005

Abstract

Mechanisms underlying the pathophysiology of minimal-change nephrotic syndrome (MCNS), the most frequent glomerular disease in children, remain elusive, but recent findings argue for a T cell dysfunction. Starting from a differential cDNA library from T cells of a patient under relapse and remission, we identified 16 transcripts specific for MCNS. All of these transcripts that were selectively up-regulated during the relapse phase of the disease were generated by alternative splicing of known genes. This abnormal RNA expression was associated with a down-regulation of serin-rich protein 75 and serin-rich protein 40, two proteins involved in mRNA splicing. Taken together, these data suggest that T cell dysfunction in MCNS is associated with abnormal mRNA splicing.

Details

Language :
English
ISSN :
0031-3998
Volume :
57
Issue :
1
Database :
MEDLINE
Journal :
Pediatric research
Publication Type :
Academic Journal
Accession number :
15531747
Full Text :
https://doi.org/10.1203/01.PDR.0000148013.53429.5B