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Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
- Source :
-
Journal of vascular research [J Vasc Res] 2004 Nov-Dec; Vol. 41 (6), pp. 509-16. Date of Electronic Publication: 2004 Oct 28. - Publication Year :
- 2004
-
Abstract
- In the present study, the effects of the bioflavonoid chrysin (5,7-dihydroxyflavone) were analyzed on the perfusion pressure of isolated mesenteric vascular bed. The vasorelaxant effects of chrysin were more potent on intact endothelium than on denuded vessels. This endothelium-dependent response induced by chrysin was inhibited in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME), KCl, tetraethylammonium (TEA), BaCl(2), TEA plus L-NAME, and ouabain plus BaCl(2), while incubations with indomethacin and glibenclamide did not modify the response induced by this bioflavonoid. Neither gap junction inhibition with carbenoxolone nor epoxyeicosatrieconic acid synthesis inhibition with sulfaphenazole (selective CYP 2C/3A inhibitor) or 7-ethoxyresorufin (selective CYP 1A inhibitor) inhibited the chrysin-induced relaxation. Moreover, chrysin increased L-NAME-sensitive cGMP accumulation in intact vascular mesenteric preparation. In conclusion, chrysin shows vasodilator effects on resistance vessels, which depend partially on the functional endothelium and appear to be related to the NO/cGMP pathway and, possibly to the release of endothelium-derived hyperpolarizing factor.<br /> (Copyright 2004 S. Karger AG, Basel.)
- Subjects :
- Animals
Arachidonic Acids physiology
Endothelium, Vascular physiology
Enzyme Inhibitors pharmacology
Flavonoids chemistry
Gap Junctions physiology
In Vitro Techniques
Male
Mesenteric Arteries physiology
Muscle, Smooth, Vascular physiology
NADPH Oxidases metabolism
NG-Nitroarginine Methyl Ester pharmacology
Potassium Channel Blockers pharmacology
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Tetraethylammonium pharmacology
Vascular Resistance
Vasodilation physiology
Flavonoids pharmacology
Mesenteric Arteries drug effects
Muscle, Smooth, Vascular drug effects
Vasodilation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1018-1172
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of vascular research
- Publication Type :
- Academic Journal
- Accession number :
- 15528933
- Full Text :
- https://doi.org/10.1159/000081807