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Special management of insulin lispro in continuous subcutaneous insulin infusion in young diabetic children: a randomized cross-over study.
- Source :
-
Hormone research [Horm Res] 2004; Vol. 62 (6), pp. 265-71. Date of Electronic Publication: 2004 Oct 22. - Publication Year :
- 2004
-
Abstract
- Objective: To compare the safety, efficacy and management of insulin lispro (LP) with regular human insulin (RH) in young diabetic children treated with continuous subcutaneous insulin infusion (CSII).<br />Study Design: 27 very young diabetic children (age 4.6 +/- 2.2 years) treated with CSII participated in an open-label, randomized cross-over multicenter study comparing 2 periods of 16 weeks of CSII with LP or RH.<br />Results: Mean daily basal rate was significantly higher during the LP period (p = 0.04). No differences were seen in changes in HbA1c levels, number of hypoglycemic events, cutaneous infections and catheter occlusions. There was no significant difference between the two treatments for preprandial and postprandial glucose values, although prandial glucose excursions tended to be lower with LP (significant at dinner, p = 0.01). Mean blood glucose levels were significantly higher at 0.00 and 3.00 a.m. during LP therapy (p < 0.05). No episode of ketoacidosis occurred during LP treatment. More parents indicated that LP made their own and the child's daily life easier (p = 0.02) and preferred LP (p = 0.01).<br />Conclusions: LP in CSII therapy in children is safe, as effective as RH, improved postprandial excursions, met the needs of young children in their daily life well, and gained their parents' satisfaction and preference. However, a shorter duration of LP resulted in hyperglycemia during the first part of the night, which must be compensated for by increasing nocturnal basal rates during this time.
- Subjects :
- Blood Glucose metabolism
Body Mass Index
Child
Child, Preschool
Cross-Over Studies
Female
Glycated Hemoglobin metabolism
Humans
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents adverse effects
Infusion Pumps, Implantable
Injections, Subcutaneous
Insulin administration & dosage
Insulin adverse effects
Insulin Lispro
Male
Parents
Postprandial Period physiology
Prospective Studies
Skin Diseases, Infectious epidemiology
Surveys and Questionnaires
Diabetes Mellitus, Type 1 drug therapy
Hypoglycemic Agents therapeutic use
Insulin analogs & derivatives
Insulin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0163
- Volume :
- 62
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Hormone research
- Publication Type :
- Academic Journal
- Accession number :
- 15523183
- Full Text :
- https://doi.org/10.1159/000081703