Back to Search
Start Over
Maternal soluble tumour necrosis factor receptor type 2 (sTNFR2) and adiponectin are both related to blood pressure during gestation and infant's birthweight.
Maternal soluble tumour necrosis factor receptor type 2 (sTNFR2) and adiponectin are both related to blood pressure during gestation and infant's birthweight.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2004 Nov; Vol. 61 (5), pp. 544-52. - Publication Year :
- 2004
-
Abstract
- Objective: Tumour necrosis factor alpha (TNF-alpha) and adiponectin are strongly related to insulin sensitivity; insulin resistance of pregnancy is a major determinant of infant's birthweight. We aimed to study the contributions of maternal serum concentrations of soluble TNF-alpha receptors (sTNFR1 and sTNFR2) and adiponectin to infant's birthweight.<br />Design: Cross-sectional, hospital-based study of insulin sensitivity during gestation.<br />Patients: Fifty-one healthy women with uncomplicated pregnancy and delivery (except for elective Caesarian section) and their healthy newborn infants. measurements Maternal blood levels of glucose, insulin, glycosylated haemaglobin (HbA1c), sTNFR1, sTNFR2 and adiponectin at delivery; cord-blood levels of sTNFR1, sTNFR2 and adiponectin.<br />Results: At delivery, maternal sTNFR2 correlated with systolic blood pressure (SBP; r = 0.38, P = 0.005). In multiple regression analyses, SBP and HbA1c were independent predictors of sTNFR2, explaining 18 and 7% of its variance, respectively; insulin resistance index (HOMA-IR), body mass index at delivery and SBP were independent predictors of adiponectin, explaining 15, 8 and 7% of its variance, respectively. Both maternal sTNFR2 and SBP were negatively correlated with infant's birthweight (r = -0.28, P = 0.04 and r = -0.36, P = 0.01 respectively, adjusted for sex and gestational age). In multivariate regression analyses, infant's sex and either maternal sTNFR2 or adiponectin were independent predictors of infant's birthweight, each explaining between 6 and 9% of birthweight variance. Further addition of maternal SBP to these models revealed that this variable was the main predictor of infant's birthweight, explaining 13% of its variance.<br />Conclusions: Maternal sTNFR2 and adiponectin are independently related to both maternal blood pressure and infant's birthweight in uncomplicated pregnancy. The contributions of the TNF-alpha system and adiponectin to hypertensive disorders of pregnancy and fetal growth merit further studies.
- Subjects :
- Adiponectin
Adult
Blood Glucose analysis
Cross-Sectional Studies
Female
Fetal Blood chemistry
Glucose Tolerance Test
Glycated Hemoglobin analysis
Humans
Infant, Newborn
Insulin blood
Receptors, Tumor Necrosis Factor, Type I analysis
Regression Analysis
Birth Weight
Blood Pressure
Intercellular Signaling Peptides and Proteins blood
Pregnancy blood
Receptors, Tumor Necrosis Factor, Type II blood
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 15521955
- Full Text :
- https://doi.org/10.1111/j.1365-2265.2004.02120.x