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The ketogenic diet does not alter brain expression of orexigenic neuropeptides.
- Source :
-
Epilepsy research [Epilepsy Res] 2004 Nov; Vol. 62 (1), pp. 35-9. - Publication Year :
- 2004
-
Abstract
- Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD.
- Subjects :
- 3-Hydroxybutyric Acid blood
Animals
Eating physiology
Energy Metabolism physiology
In Situ Hybridization
Ketones metabolism
Mice
Mice, Inbred C57BL
RNA, Messenger biosynthesis
RNA, Messenger genetics
Seizures chemically induced
Seizures diet therapy
Brain Chemistry drug effects
Epilepsy diet therapy
Galanin biosynthesis
Neuropeptide Y biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0920-1211
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 15519130
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2004.08.002