Impact of prolonged treatment with trimethoprim-sulfamethoxazole on the human gut flora.

Authors :: Kofteridis DP
Maraki S
Mixaki I
Mantadakis E
Samonis G
Source :: Scandinavian journal of infectious diseases [Scand J Infect Dis] 2004; Vol. 36 (10), pp. 771-2.
Publication Year :: 2004
Abstract: The case of a mentally ill man inadvertently treated with trimethoprim-sulfamethoxazole (TMP-SMX) for 2 y is presented. Quantitative stool cultures revealed a substantially suppressed Gram-negative aerobic flora, while Enterococcus spp. and anaerobes were not affected. Yeasts were moderately increased. TMP-SMX represents an attractive antimicrobial for immunocompromized patients who need the integrity of their intestinal anaerobic flora for colonization resistance.

Subjects :: Adult
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Humans
Intestinal Mucosa microbiology
Long-Term Care
Male
Risk Assessment
Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
Urinary Catheterization adverse effects
Urinary Catheterization methods
Urinary Tract Infections diagnosis
Urinary Tract Infections etiology
Intestinal Mucosa drug effects
Mental Disorders diagnosis
Trimethoprim, Sulfamethoxazole Drug Combination adverse effects
Urinary Tract Infections drug therapy

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