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Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody.
- Source :
-
Infection and immunity [Infect Immun] 2004 Nov; Vol. 72 (11), pp. 6694-8. - Publication Year :
- 2004
-
Abstract
- Ciliated ependymal cells line the ventricular surfaces and aqueducts of the brain. In ex vivo experiments, pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal cell disruption. Wild-type pneumococci and pneumococci deficient in pneumolysin caused ciliary slowing, but penicillin lysis of wild-type, not pneumolysin-deficient, pneumococci increased the extent of ciliary inhibition. This effect was abolished by antipneumolysin antibody. Ependymal ciliary stasis by purified pneumolysin was also blocked by the addition of antipneumolysin monoclonal antibodies. These data show that antibiotic lysis of Streptococcus pneumoniae can be detrimental to the ciliated ependyma and that antipneumolysin antibody may have a therapeutic potential.
- Subjects :
- Animals
Antibodies, Bacterial immunology
Antibodies, Bacterial pharmacology
Antibodies, Monoclonal immunology
Antibodies, Monoclonal pharmacology
Bacteriolysis drug effects
Bacteriolysis immunology
Penicillins pharmacology
Rats
Bacterial Proteins immunology
Cilia drug effects
Ependyma drug effects
Streptococcus pneumoniae pathogenicity
Streptolysins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 72
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 15501805
- Full Text :
- https://doi.org/10.1128/IAI.72.11.6694-6698.2004