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Syntheses of photolabile novobiocin analogues.

Syntheses of photolabile novobiocin analogues.

Authors :
Shen G
Yu XM
Blagg BS
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Dec 06; Vol. 14 (23), pp. 5903-6.
Publication Year :
2004

Abstract

Novobiocin was recently shown to inhibit Hsp90 through a previously unrecognized C-terminal ATP binding site. Although the N-terminal region of Hsp90 has been solved by X-ray crystallography, the C-terminal region has not. In an effort to elucidate the C-terminal binding site of Hsp90, four photolabile analogues of novobiocin were prepared.

Details

Language :
English
ISSN :
0960-894X
Volume :
14
Issue :
23
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
15501066
Full Text :
https://doi.org/10.1016/j.bmcl.2004.09.017