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Refined morphologic criteria for tubular carcinoma to retain its favorable outcome status in contemporary breast carcinoma patients.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2004 Nov; Vol. 122 (5), pp. 728-39. - Publication Year :
- 2004
-
Abstract
- We studied outcomes of 147 patients with stage I/II grade 1 (32 pure tubular, 115 ductal) carcinoma treated with breast-conserving therapy to evaluate the prognostic usefulness of standard and recently proposed revised criteria for tubular (tubularity percentage [proportion of neoplastic cells adjacent to open lumens], nuclear grade, and mitoses) and ductal carcinoma. Carcinomas with less than 70% tubularity were ductal. Carcinomas with 70% or more tubularity were divided into those with occasional grade 2 nuclei and mitoses and those with pure grade 1 nuclei and rare or no mitoses. The 10-year disease-free survival for patients with pure ductal vs pure tubular carcinoma was 91% vs 96% (P = .036). Overall survival rates were similar (85% vs 89%; P = .161). With the recently proposed criteria, neoplasms with less than 70% tubularity; 70% or more tubularity and occasional grade 2 nuclei and mitoses; and 70% or more tubularity, pure grade 1 nuclei, and rare mitoses had 10-year disease-free survival rates of 88%, 93%, and 100% (P < .001) and 10-year overall survival rates of 85%, 88%, and 94%, respectively (P < .001). Tubular carcinoma as a distinct morphologic entity should be restricted to neoplasms with 70% or more tubularity, pure grade 1 nuclei, and rare mitoses. Other definitions of tubular carcinoma do not guarantee the excellent prognosis.
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma mortality
Breast Neoplasms metabolism
Breast Neoplasms mortality
Carcinoma, Intraductal, Noninfiltrating metabolism
Carcinoma, Intraductal, Noninfiltrating mortality
Female
Humans
Middle Aged
Neoplasm Staging
Prognosis
Survival Analysis
Adenocarcinoma pathology
Breast Neoplasms pathology
Carcinoma, Intraductal, Noninfiltrating pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 122
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 15491969
- Full Text :
- https://doi.org/10.1309/9FEP-8U8A-UGQN-GY3V