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NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish.
- Source :
-
Neuroscience letters [Neurosci Lett] 2004 Nov 11; Vol. 370 (2-3), pp. 248-51. - Publication Year :
- 2004
-
Abstract
- In Mg2+ -free aCSF, bursting discharges were induced in the posterior telencephalon of zebrafish following an electrical stimulation of the anterior telencephalon. The bursting discharges were partially reduced by CNQX (10 microM), an AMPA receptor antagonist, and the remaining activity was completely blocked by an additional treatment of APV (50 microM), an NMDA receptor antagonist. Long-term potentiation that lasted more than 1 h was also induced after 20 min of perfusion with KCl (10 mM). The degree of KCl-induced long-term potentiation (K-LTP) was reduced when a concomitant electrical stimulation was not delivered during a KCl perfusion. K-LTP was blocked by APV (50 microM) but not by nifedipine (1 microM), an L-type Ca2+ channel blocker. Furthermore, K-LTP was not induced in the presence of a broad spectrum inhibitor for protein kinases, H-7 (10 microM). These results suggest that NMDA receptors and protein kinases play important roles in the synaptic plasticity of the zebrafish brain.
- Subjects :
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology
Animals
Calcium Channel Blockers pharmacology
Drug Interactions
Electric Stimulation methods
Enzyme Inhibitors pharmacology
Excitatory Amino Acid Agonists pharmacology
Excitatory Amino Acid Antagonists pharmacology
In Vitro Techniques
Long-Term Potentiation drug effects
Long-Term Potentiation radiation effects
Magnesium metabolism
Nifedipine pharmacology
Potassium Chloride pharmacology
Receptors, N-Methyl-D-Aspartate drug effects
Receptors, N-Methyl-D-Aspartate radiation effects
Telencephalon drug effects
Telencephalon radiation effects
Time Factors
Valine pharmacology
Zebrafish
Long-Term Potentiation physiology
Receptors, N-Methyl-D-Aspartate physiology
Telencephalon physiology
Valine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 370
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 15488332
- Full Text :
- https://doi.org/10.1016/j.neulet.2004.08.037