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The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
- Source :
-
Neuroscience letters [Neurosci Lett] 2004 Nov 11; Vol. 370 (2-3), pp. 236-40. - Publication Year :
- 2004
-
Abstract
- Osteoarthritis (OA) is a widespread condition affecting the elderly population. One of the most prominent features but least studied symptoms is chronic pain associated with OA. The study objective was to determine pain endpoints in rats with monosodium iodoacetate (MIA) induced OA, and to investigate the efficacy of common nociceptive agents. Sprague-Dawley rats received an intraarticular injection of either 25 microl 80 mg/ml MIA or 25 microl 0.9% sterile saline into the right knee joint. Changes in von Frey thresholds and latencies to stroking with a cotton bud (punctate and dynamic allodynia, respectively) were measured pre- and for up to 10 weeks post-intraarticular injection. Changes in hind paw weight distribution were also determined. Both punctate allodynia and a weight bearing deficit were observed in MIA-treated rats for up to 10 weeks. Interestingly, dynamic allodynia was not detected at any time point tested. Morphine (0.3-3 mg/kg, s.c.) and tramadol (3-100 mg/kg, p.o.) dose-dependently inhibited punctate allodynia and partially reversed weight bearing deficit. In conclusion, the MIA model of OA is reproducible and mimics OA pain in humans. Analgesic drug studies indicate this model may be useful for investigating chronic nociceptive pain.
- Subjects :
- Analysis of Variance
Animals
Chronic Disease
Enzyme Inhibitors
Functional Laterality
Hyperalgesia physiopathology
Male
Morphine therapeutic use
Osteoarthritis drug therapy
Osteoarthritis physiopathology
Pain drug therapy
Pain Measurement methods
Rats
Rats, Sprague-Dawley
Time Factors
Weight-Bearing physiology
Disease Models, Animal
Iodoacetates
Osteoarthritis chemically induced
Pain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 370
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 15488329
- Full Text :
- https://doi.org/10.1016/j.neulet.2004.08.023