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Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2004 Nov 01; Vol. 190 (9), pp. 1631-41. Date of Electronic Publication: 2004 Sep 28. - Publication Year :
- 2004
-
Abstract
- Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.
- Subjects :
- Adult
Africa, Western
Case-Control Studies
DNA isolation & purification
DNA metabolism
Deoxyribonucleases, Type II Site-Specific metabolism
Disease Transmission, Infectious
Female
Gene Frequency
Haplotypes
Humans
Male
Middle Aged
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Receptors, Calcitriol genetics
Tuberculosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 190
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15478069
- Full Text :
- https://doi.org/10.1086/424462