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Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.
- Source :
-
Genomics [Genomics] 2004 Oct; Vol. 84 (4), pp. 637-46. - Publication Year :
- 2004
-
Abstract
- The EPB41 (protein 4.1) genes epitomize the resourcefulness of the mammalian genome to encode a complex proteome from a small number of genes. By utilizing alternative transcriptional promoters and tissue-specific alternative pre-mRNA splicing, EPB41, EPB41L2, EPB41L3, and EPB41L1 encode a diverse array of structural adapter proteins. Comparative genomic and transcript analysis of these 140- to 240-kb genes indicates several unusual features: differential evolution of highly conserved exons encoding known functional domains interspersed with unique exons whose size and sequence variations contribute substantially to intergenic diversity; alternative first exons, most of which map far upstream of the coding regions; and complex tissue-specific alternative pre-mRNA splicing that facilitates synthesis of functionally different complements of 4.1 proteins in various cells. Understanding the splicing regulatory networks that control protein 4.1 expression will be critical to a full appreciation of the many roles of 4.1 proteins in normal cell biology and their proposed roles in human cancer.<br /> (Copyright 2004 Elsevier Inc.)
- Subjects :
- Animals
Cytoskeletal Proteins
Exons
Humans
Introns
Membrane Proteins genetics
Mice
Microfilament Proteins
Protein Isoforms
Protein Structure, Tertiary
RNA, Messenger genetics
RNA, Messenger metabolism
Alternative Splicing
Biological Evolution
Blood Proteins genetics
Microtubule-Associated Proteins genetics
RNA Precursors genetics
RNA Processing, Post-Transcriptional
Subjects
Details
- Language :
- English
- ISSN :
- 0888-7543
- Volume :
- 84
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 15475241
- Full Text :
- https://doi.org/10.1016/j.ygeno.2004.06.004