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Effect of probucol dosage on plasma lipid and lipoprotein levels and on protection of low density lipoprotein against in vitro oxidation in humans.
- Source :
-
Arteriosclerosis and thrombosis : a journal of vascular biology [Arterioscler Thromb] 1992 Mar; Vol. 12 (3), pp. 318-24. - Publication Year :
- 1992
-
Abstract
- To determine whether probucol's ability to confer antioxidant protection to low density lipoprotein (LDL) could be dissociated from its ability to lower high density lipoprotein (HDL) cholesterol, 17 hypercholesterolemic patients were treated with either a standard dose, 1 g/day (4 tablets), or a low dose, 250 mg/day (1 tablet), of probucol for a 6-month period. Effects of therapy on lipoprotein levels and on susceptibility of LDL to in vitro oxidation were measured at frequent intervals. Probucol levels in plasma LDL rose less rapidly in the 1-tablet group but were nearly 50% of levels in the 4-tablet group after 6 months. HDL cholesterol and apolipoprotein A-1 decreased 17.6% and 27.9%, respectively, in the 1-tablet group compared with 28.0% and 38.3%, respectively, in the 4-tablet group (p = 0.07 and p = 0.06). In the 4-tablet group, LDL was protected from copper and endothelial cell-mediated oxidation after 2 months of therapy. In the 1-tablet group, equal degrees of protection occurred, but only after 6 months of therapy. In the whole study group, the decrease in LDL susceptibility to copper or endothelial cell-mediated oxidative modification was correlated with the content of probucol in LDL (r = 0.73, r = 0.65, p less than 0.005). Additionally, the decrease in HDL cholesterol level was correlated with the increase in protection to LDL from oxidative modification (r = 0.67 for copper, r = 0.58 for endothelial cells, p less than 0.05 for both) and also with the content of probucol in LDL (r = 0.6, p = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Cholesterol, HDL blood
Female
Humans
Hypercholesterolemia blood
Macrophages drug effects
Macrophages metabolism
Male
Probucol pharmacology
Probucol therapeutic use
Hypercholesterolemia drug therapy
Lipid Peroxidation drug effects
Lipids blood
Lipoproteins blood
Lipoproteins, LDL blood
Probucol administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1049-8834
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis and thrombosis : a journal of vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 1547191
- Full Text :
- https://doi.org/10.1161/01.atv.12.3.318