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Impaired declarative memory in depressed patients is slow to recover: clinical experience.
- Source :
-
Pharmacopsychiatry [Pharmacopsychiatry] 2004 Jul; Vol. 37 (4), pp. 147-51. - Publication Year :
- 2004
-
Abstract
- Introduction: The temporal course of recovery of depressed patients' cognitive impairment is not fully understood.<br />Methods: We used the California Verbal Learning Test (CVLT) to test declarative memory in 24 depressed patients before and after 35 days of antidepressive treatment as well as after long-term follow-up (> 12 months) in order to relate improvement of depression to recovery of cognitive impairment.<br />Results: Patients with complete remission after 35 days had generally been less impaired at baseline. The disturbance of declarative memory in treatment responders as well as in non-responders did not change from baseline to end of treatment (day 35). However, our results revealed normal values in the CVLT sum score as well as in measures of short- and long-delay free-recall measures in both groups after long-term full remission.<br />Discussion: We conclude that clinical response to antidepressive treatment precedes improvement of declarative memory. A low degree of impairment of declarative memory is associated with early complete remission of depression.
- Subjects :
- Amitriptyline administration & dosage
Antidepressive Agents, Tricyclic administration & dosage
Depressive Disorder, Major diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Hydrocortisone analysis
Language Tests
Male
Middle Aged
Paroxetine administration & dosage
Remission Induction
Saliva chemistry
Selective Serotonin Reuptake Inhibitors administration & dosage
Severity of Illness Index
Surveys and Questionnaires
Verbal Learning
Amitriptyline therapeutic use
Antidepressive Agents, Tricyclic therapeutic use
Depressive Disorder, Major drug therapy
Depressive Disorder, Major psychology
Memory Disorders etiology
Paroxetine therapeutic use
Recovery of Function
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0176-3679
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pharmacopsychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15467969
- Full Text :
- https://doi.org/10.1055/s-2004-827168