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The effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague-Dawley rats.
- Source :
-
The Journal of toxicological sciences [J Toxicol Sci] 2004 Aug; Vol. 29 (3), pp. 187-93. - Publication Year :
- 2004
-
Abstract
- Testosterone propionate (TP) was supplemented to male rats for assessment of its ameliorating effect on testicular toxicity with thiamphenicol (TAP). A total of 20 male Sprague-Dawley rats were treated orally with TAP at 200 mg/kg/day for up to 4 weeks. In addition, 5 male rats were allotted to the control group receiving vehicle only. Ten of the 20 treated rats had a Silastic capsule (containing about 80 mg of TP) implanted in the dorsal skin at Week 2 and assigned to the TAP-TP group, while the other 10 treated rats were in the TAP group. After Weeks 3 and 4, five of both treated groups were examined for weight and histology of the testis and accessory genital glands, and for staging analysis of the seminiferous tubules. The same parameters were also assessed in the control group after Week 4. Weights and morphology of the seminal vesicle and prostate recovered remarkably from the TAP toxicity after TP supplement. However, no ameliorating effects of TP were obtained for the testis in either weight, morphology, or staging analysis of the seminiferous tubules.
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Body Weight drug effects
Male
Organ Size drug effects
Rats
Rats, Sprague-Dawley
Testis pathology
Testosterone Propionate administration & dosage
Thiamphenicol administration & dosage
Anti-Bacterial Agents toxicity
Testis drug effects
Testosterone Propionate pharmacology
Thiamphenicol toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0388-1350
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of toxicological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15467268
- Full Text :
- https://doi.org/10.2131/jts.29.187