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Effects of magnesium on cardiac excitation-contraction coupling.
- Source :
-
Journal of the American College of Nutrition [J Am Coll Nutr] 2004 Oct; Vol. 23 (5), pp. 514S-517S. - Publication Year :
- 2004
-
Abstract
- Objective: Magnesium regulates a large number of cellular processes. Small changes in intracellular free Mg(2+) ([Mg(2+)](i)) may have important effects on cardiac excitability and contractility. We investigated the effects of [Mg(2+)](i) on cardiac excitation-contraction coupling.<br />Methods: We used our ionic-metabolic model that incorporates equations for Ca(2+) and Mg(2+) buffering and transport by ATP and ADP and equations for MgATP regulation of ion transporters (Na(+)-K(+) pump, sarcolemmal and sarcoplasmic Ca(2+) pumps).<br />Results: Model results indicate that variations in cytosolic Mg(2+) level might sensitively affect diastolic and systolic Ca(2+), sarcoplasmic Ca(2+) content, Ca(2+) influx through L-type channels, efficiency of the Na(+)/Ca(2+) exchanger and action potential shape. The analysis suggests that the most important reason for the observed effects is a modified normal function of sarcoplasmic Ca(2+)-ATPase pump by altered diastolic MgATP levels.<br />Conclusion: The model is able to reproduce qualitatively a sequence of events that correspond well with experimental observations during cardiac excitation-contraction coupling in mammalian ventricular myocytes.
- Subjects :
- Action Potentials
Calcium-Transporting ATPases
Electric Conductivity
Humans
Ion Transport
Models, Biological
Myocardium cytology
Sarcoplasmic Reticulum
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Adenosine Diphosphate metabolism
Adenosine Triphosphate metabolism
Calcium metabolism
Ion Pumps metabolism
Magnesium metabolism
Myocardium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0731-5724
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the American College of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 15466954
- Full Text :
- https://doi.org/10.1080/07315724.2004.10719392