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Volumetric neural correlates of antisaccade eye movements in first-episode psychosis.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2004 Oct; Vol. 161 (10), pp. 1918-21. - Publication Year :
- 2004
-
Abstract
- Objective: The authors investigated the structural brain correlates of antisaccade performance.<br />Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography.<br />Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate.<br />Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.
- Subjects :
- Adult
Brain physiopathology
Brain Mapping
Cerebral Cortex physiopathology
Female
Humans
Male
Neural Inhibition physiology
Reaction Time physiology
Regression Analysis
Schizophrenia physiopathology
Schizophrenic Psychology
Task Performance and Analysis
Visual Perception physiology
Brain anatomy & histology
Magnetic Resonance Imaging
Psychomotor Performance physiology
Saccades physiology
Schizophrenia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0002-953X
- Volume :
- 161
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15465994
- Full Text :
- https://doi.org/10.1176/ajp.161.10.1918