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Drapc1 expression during mouse embryonic development.
- Source :
-
Gene expression patterns : GEP [Gene Expr Patterns] 2004 Oct; Vol. 4 (6), pp. 755-62. - Publication Year :
- 2004
-
Abstract
- We identified the mouse homolog of human DRAPC1 (APCDD1) gene, shown to be a target of Wnt/beta-catenin signaling pathway in cancer cell lines. Analysis of its spatiotemporal expression in mouse embryos from E7.5 to E14 showed that Drapc1 is expressed during development of the extraembryonic structures, nervous system, vascular system and inner ear. In addition, Drapc1 is expressed in the mesenchyme of several developing organs at sites of epithelio-mesenchymal interactions. Drapc1 expression was also found in the hair follicles of the adult mouse skin. Similarity of Drapc1 expression pattern to location of active beta-catenin in developing mouse embryo further suggests that mouse Drapc1 is a novel in vivo target gene of Wnt/beta-catenin signaling pathway.
- Subjects :
- Amino Acid Sequence
Animals
Female
Hippocampus embryology
Humans
In Situ Hybridization
Membrane Proteins
Mice
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
Time Factors
Tissue Distribution
Adenomatous Polyposis Coli Protein biosynthesis
Brain embryology
Gene Expression Regulation, Developmental
Intracellular Signaling Peptides and Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1567-133X
- Volume :
- 4
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gene expression patterns : GEP
- Publication Type :
- Academic Journal
- Accession number :
- 15465500
- Full Text :
- https://doi.org/10.1016/j.modgep.2004.03.006