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Graft versus leukemia. VI. Adoptive immunotherapy in combination with chemoradiotherapy for spontaneous leukemia-lymphoma in AKR mice.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 1975 Nov; Vol. 55 (5), pp. 1227-9. - Publication Year :
- 1975
-
Abstract
- A three-step treatment plan incorporating adoptive immunotherapy and chemoradiotherapy was used to treat AKR (H-2k) mice bearing spontaneous leukemia-lymphoma (SLL). 1) Leukemic mice were treated with chemoradiotherapy for immunosuppression and leukemia cytoreduction. 2) To introduce a graft-versus-leukemia reaction against residual malignant cells, the immunosuppressed AKR mice were given immunocompetent cells from H-2 mismatched DBA/2 (H-2d) donors. 3) To "rescue" the AKR hosts from incipient graft-versus-host disease, the mismatched DBA/2 cells were killed with combination chemotherapy, and cells from allogeneic H-2 matched RF (H-2k) donors were administered to restore hematopoiesis. Leukemic AKR mice thus treated had significant prolongation of their median survival time and a higher 60-day survival rate post treatment than did untreated controls, chemoradiotherapy controls, or control mice that received chemoradiotherapy plus cells from syngeneic donors. Therefore, adoptive immunotherapy may be useful as an adjunct to conventional therapy for treatment of SLL in AKR mice.
- Subjects :
- Amphotericin B therapeutic use
Animals
Antibodies, Neoplasm
Cyclophosphamide therapeutic use
Leukemia, Experimental drug therapy
Leukemia, Experimental immunology
Leukemia, Experimental radiotherapy
Lomustine therapeutic use
Mice
Mice, Inbred AKR
Graft vs Host Reaction drug therapy
Immunization, Passive
Leukemia, Experimental therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8874
- Volume :
- 55
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 1546
- Full Text :
- https://doi.org/10.1093/jnci/55.5.1227