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In normoglycemic Koreans, insulin resistance and adipocity are independently correlated with high blood pressure.

Authors :
Sung KC
Kim BJ
Kim BS
Kang JH
Lee MH
Park JR
Rhee EJ
Lee WY
Kim SW
Kim H
Lee KB
Ryu SH
Source :
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2004 Oct; Vol. 68 (10), pp. 898-902.
Publication Year :
2004

Abstract

Background: There is some controversy about the role of insulin resistance (IR) in the regulation of blood pressure (BP). Moreover, a large study of the association between BP and IR has not been conducted in normal glucose tolerance Asians. The present study investigated the relationships between IR, body mass index (BMI) and waist circumference and BP in normoglycemic Koreans.<br />Methods and Results: Anthropometric indices of adiposity, metabolic variables (fasting serum insulin and a homeostasis model assessment (HOMA) index of insulin sensitivity), BP and several cardiovascular risk factors were measured during a cross-sectional survey of 49,076 normoglycemic Korean subjects. A high BP was defined as a systolic BP >/=140 mmHg or a diastolic BP >/=90 mmHg. The prevalence of high BP by HOMA grading was 0.985 (95% confidence interval (CI) 0.857-1.132, p=0.835), 1.180 (95% CI 1.032-1.350, p=0.016), 1.289 (95% CI 1.129-1.472, p<0.001), and 1.540 (95% CI 1.341-1.768, p<0.001) times higher in subjects in the second, third, fourth, and fifth quintiles, respectively, compared with those in the first quintile. In addition, age, sex, waist circumference and BMI were found to be significantly associated with a high BP.<br />Conclusion: IR, BMI and waist circumference are independently correlated with high BP in normoglycemic Koreans.

Details

Language :
English
ISSN :
1346-9843
Volume :
68
Issue :
10
Database :
MEDLINE
Journal :
Circulation journal : official journal of the Japanese Circulation Society
Publication Type :
Academic Journal
Accession number :
15459461
Full Text :
https://doi.org/10.1253/circj.68.898