Back to Search
Start Over
An active insect kinin analog with 4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif.
- Source :
-
Biopolymers [Biopolymers] 2004 Dec 05; Vol. 75 (5), pp. 412-9. - Publication Year :
- 2004
-
Abstract
- The insect kinins are potent diuretic peptides that preferentially form a cis-Pro, type VI beta-turn. An insect kinin analog containing (2S,4S)-4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif, demonstrates significant activity in the physiological range in a cricket diuretic assay. This is the first instance of a 4-aminopyroglutamate analog of a peptide with a preference for a type VI turn that demonstrates significant bioactivity. The results provide further confirmatory evidence for the active conformation of the insect kinins, and a new scaffold with which to design biostable, peptidomimetic analogs capable of disrupting critical insect kinin-regulated processes in insects.<br /> (Copyright 2004 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Diuretics chemistry
Diuretics pharmacology
Gryllidae drug effects
Insect Proteins pharmacology
Kinins pharmacology
Magnetic Resonance Spectroscopy
Oligopeptides pharmacology
Protein Structure, Secondary
Insect Proteins chemistry
Kinins chemistry
Oligopeptides chemistry
Pyrrolidonecarboxylic Acid analogs & derivatives
Pyrrolidonecarboxylic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3525
- Volume :
- 75
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biopolymers
- Publication Type :
- Academic Journal
- Accession number :
- 15457492
- Full Text :
- https://doi.org/10.1002/bip.20155