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Adaptive doses of irradiation-an approach to a new therapy concept for bladder cancer?
- Source :
-
Radiation and environmental biophysics [Radiat Environ Biophys] 2004 Dec; Vol. 43 (4), pp. 271-6. Date of Electronic Publication: 2004 Sep 29. - Publication Year :
- 2004
-
Abstract
- Radiation adaptive response in terms of induced radioresistance or hyperradiosensitivity, has been studied in HCV29 (human bladder epithelium) and RT4 (human bladder carcinoma) cell lines. After pre-irradiation doses of 0.05 Gy or 0.1 Gy, HCV29 cells showed induced radioresistance, whereas after pre-irradiation doses of 0.05 Gy, 0.1 Gy, 0.2 Gy, and 0.5 Gy, the RT4 cells clearly showed hyperradiosensitivity. On the basis of these results, an approach has been developed that may lead to a concept for a new radiotherapeutic regimen of bladder cancer that includes protection of normal cells, on the one hand, and the potential of tumor cell damage, on the other hand. These findings need to be confirmed in further studies for the benefit of the patients.
- Subjects :
- Cell Line
Dose-Response Relationship, Radiation
Humans
Radiation Dosage
Radiation Protection methods
Radiotherapy methods
Treatment Outcome
Adaptation, Physiological radiation effects
Cell Survival radiation effects
Radiation Tolerance radiation effects
Urinary Bladder Neoplasms pathology
Urinary Bladder Neoplasms radiotherapy
Urothelium cytology
Urothelium radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0301-634X
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Radiation and environmental biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 15455244
- Full Text :
- https://doi.org/10.1007/s00411-004-0256-5