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Antioxidant effect of simvastatin is not enhanced by its association with alpha-tocopherol in hypercholesterolemic patients.
- Source :
-
Free radical biology & medicine [Free Radic Biol Med] 2004 Nov 01; Vol. 37 (9), pp. 1440-8. - Publication Year :
- 2004
-
Abstract
- Among the pleiotropic effects of statins, their antioxidant action may be involved in their protective effects. Thus, we investigated the antioxidant effect of simvastatin, associated or not with alpha-tocopherol, on levels of electronegative low-density lipoprotein (LDL-), nitrotyrosine, thiols (homocysteine, glutathione, cysteine, methionine), and lipid-soluble antioxidants in blood plasma of hypercholesterolemic subjects. In this study, 25 hypercholesterolemic subjects were treated for 2 months with simvastatin (20 mg/day) and with simvastatin (20 mg/day) + alpha-tocopherol (400 IU/day). Concentrations of thiols were determined by high-performance capillary electrophoresis-laser-induced fluorescene. Lipid-soluble antioxidants were determined by HPLC, and LDL-, and nitrotyrosine by ELISA. Simvastatin, independent of its association with alpha-tocopherol, reduced plasma concentrations of LDL-, nitrotyrosine, total cholesterol, and LDL cholesterol and the LDL cholesterol/HDL cholesterol ratio. Neither simvastatin nor simvastatin plus alpha-tocopherol altered plasma levels of the thiols analyzed. alpha-Tocopherol did not change the antioxidant effect of simvastatin on the levels of LDL- and nitrotyrosine in hypercholesterolemic subjects. The reduction of LDL- and nitrotyrosine by simvastatin seems to be related to the pleiotropic effects of this statin, and it may have an important protective effect against endothelial dysfunction and atherosclerosis.
- Subjects :
- Cholesterol blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Female
Humans
Hypercholesterolemia blood
Lipids blood
Male
Middle Aged
Sulfhydryl Compounds blood
Triglycerides blood
Anticholesteremic Agents therapeutic use
Antioxidants pharmacology
Hypercholesterolemia drug therapy
Simvastatin therapeutic use
alpha-Tocopherol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0891-5849
- Volume :
- 37
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Free radical biology & medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15454283
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2004.07.019