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Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection.
- Source :
-
Journal of virology [J Virol] 2004 Oct; Vol. 78 (20), pp. 11411-5. - Publication Year :
- 2004
-
Abstract
- ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.
- Subjects :
- Animals
Baculoviridae genetics
Baculoviridae metabolism
Cells, Cultured
Chlorocebus aethiops
Green Fluorescent Proteins
Herpes Simplex pathology
Humans
Luminescent Proteins genetics
Luminescent Proteins metabolism
Microscopy, Video
Neoplasm Proteins genetics
Nuclear Proteins genetics
Promyelocytic Leukemia Protein
Recombinant Fusion Proteins metabolism
Transcription Factors genetics
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases
Vero Cells cytology
Vero Cells virology
Cell Nucleus Structures pathology
Herpesvirus 1, Human pathogenicity
Immediate-Early Proteins metabolism
Neoplasm Proteins metabolism
Nuclear Proteins metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 78
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 15452264
- Full Text :
- https://doi.org/10.1128/JVI.78.20.11411-11415.2004