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Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle.
- Source :
-
Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2004 Oct; Vol. 12 (10), pp. 826-33. - Publication Year :
- 2004
-
Abstract
- Objective: Determine (1) the site-associated response of articular cartilage of the equine distal metacarpal condyle to training at a young age as assessed by changes in indentation stiffness and alterations in cartilage structure and composition, and (2) relationships between indentation stiffness and indices of cartilage structure and composition.<br />Method: Experimental animals (n=6) were trained on a track (increasing exercise to 1km/day by 5 months); controls (n=6) were pasture-reared. Animals were euthanized at 18 months and four osteochondral samples were harvested per metacarpal condyle from dorsal-medial, dorsal-lateral, palmar-medial, and palmar-lateral aspects. Cartilage was analyzed for India ink staining (quantified as reflectance score (RS)), short-term indentation stiffness (sphere-ended, 0.4mm diameter), thickness, and biochemical composition.<br />Results: Cartilage structural, biochemical and biomechanical properties varied markedly with site in the joint. Sites just medial and just lateral to the sagittal ridge showed signs of early degeneration, with relatively low RS, indentation stiffness, and collagen content, and relatively high water content. Effects of exercise and side (left vs right) were not detected for any measure. Overall, indentation stiffness correlated positively with RS and collagen content, and inversely with thickness and water content.<br />Conclusion: Gentle exercise-imposed mechanical stimulation did not markedly affect articular cartilage function or structure. However, the marked site-associated variation suggests that biomechanical environment can initiate degenerative changes in immature cartilage during joint growth and maturation.
- Subjects :
- Animals
Biomechanical Phenomena
Body Water metabolism
Cartilage, Articular anatomy & histology
Cartilage, Articular metabolism
Collagen metabolism
Horses anatomy & histology
Horses metabolism
Metacarpus anatomy & histology
Metacarpus metabolism
Principal Component Analysis
Cartilage, Articular physiology
Horses physiology
Metacarpus physiology
Physical Conditioning, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1063-4584
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Osteoarthritis and cartilage
- Publication Type :
- Academic Journal
- Accession number :
- 15450533
- Full Text :
- https://doi.org/10.1016/j.joca.2004.07.001