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Phage nucleoprotein-psoralen interaction: quantitative characterization of dark and photoreactions.
- Source :
-
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 1992 Jan; Vol. 12 (1), pp. 9-27. - Publication Year :
- 1992
-
Abstract
- The irradiation of the phage T7 system containing psoralen as photosensitizer causes many processes, each of them leading to phage inactivation. These processes include the UV-induced photoreactions in the phage nucleic acid, and photoreactions in the nucleic acid sensitized by either psoralen or psoralen photobreakdown products. In addition the intercalation of the psoralen molecule itself in the phage nucleic acid as well as the psoralen photobreakdown products cause phage inactivation. Under appropriate experimental conditions these reactions can be studied and characterized separately. The quantitative characteristics (e.g. inactivation cross-section, action spectra and index for dark genotoxicity) are demonstrated for different linear and angular psoralens. Some theoretical and practical consequences of the results obtained are discussed.
- Subjects :
- Darkness
Escherichia coli drug effects
Escherichia coli physiology
Escherichia coli radiation effects
Furocoumarins metabolism
Light
Nucleoproteins radiation effects
T-Phages physiology
T-Phages radiation effects
Ultraviolet Rays
Furocoumarins pharmacology
Nucleoproteins metabolism
T-Phages drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1011-1344
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of photochemistry and photobiology. B, Biology
- Publication Type :
- Academic Journal
- Accession number :
- 1542090
- Full Text :
- https://doi.org/10.1016/1011-1344(92)85015-m