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[Multifactor analysis of relationship between the biological exposure to iodine and hypothyroidism].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2004 Jul 17; Vol. 84 (14), pp. 1171-4. - Publication Year :
- 2004
-
Abstract
- Objective: To assess the relationship between the biological exposure to iodine and hypothyroidism.<br />Methods: Logistic regression model was used to analyze the risk factors of hypothyroidism, according to the epidemiologic data of 3761 adults in 3 kinds of rural communities: mild iodine deficiency area (4 natural villages in Panshan County, Liaoning Province), more than adequate iodine (7 natural villages of Zhangwu County, Liaoning Province), and excessive iodine area (2 natural villages of Huanghua City, Hebei Province).<br />Results: More than adequate iodine and excessive iodine were independent risk factors of subclinical hypothyroidism (OR = 3.172 and 6.391, P < 0.05) and overt hypothyroidism (OR = 3.696 and 9.213, P < 0.05). When interactions of iodine exposure and thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TgAb) were included, more than adequate iodine was still a risk factor of subclinical hypothyroidism (OR = 2.788, P < 0.01), but had no such effect on overt hypothyroidism. Interaction of more than adequate iodine and positive TgAb significantly affected subclinical hypothyroidism and overt hypothyroidism (OR = 2.656 and 3.347, P < 0.05).<br />Conclusion: More than adequate and excessive iodine exposure are independent risk factors of hypothyroidism. The risk of hypothyroidism grows up and thyroid dysfunction becomes more serious with the increasing of the biological exposure to iodine.
- Subjects :
- Adult
Autoantigens immunology
Causality
China epidemiology
Female
Humans
Hypothyroidism chemically induced
Iodide Peroxidase immunology
Iodine deficiency
Iron-Binding Proteins immunology
Logistic Models
Male
Prevalence
Risk Factors
Hypothyroidism epidemiology
Iodine adverse effects
Water Supply analysis
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 84
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 15387978