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Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.
- Source :
-
Transplantation [Transplantation] 2004 Sep 27; Vol. 78 (6), pp. 919-24. - Publication Year :
- 2004
-
Abstract
- Background: In this study, we determined whether Campath-1H induction followed by sirolimus monotherapy inhibited alloantibody production in renal transplantation. Second, we evaluated the correlation between human leukocyte antigen (HLA) antibody production and serum creatinine levels.<br />Methods: Sera were taken 1 to 24 months after transplantation from 24 patients treated with Campath-1H and sirolimus and tested for serum creatinine and HLA-specific antibody by using flow cytometry and enzyme-linked immunosorbent assay.<br />Results: Ten (42%) of the 24 patients treated with Campath-1H and sirolimus produced HLA antibodies. Six of these 10 developed both donor-specific antibodies (DSAs) and non-donor-specific antibodies (NDSAs), whereas only NDSAs were detected in the other four patients. In patients with biopsy-diagnosed humoral rejection (C4d+), serum levels of both DSA and NDSA significantly correlated with patient serum creatinine levels. Rejection treatment successfully reduced both DSAs and NDSAs and reversed humoral rejection.<br />Conclusions: The numeric relationship between serum creatinine and DSA levels suggests a causal relationship between alloantibody and transplant rejection.
- Subjects :
- Alemtuzumab
Antibodies, Monoclonal, Humanized
Antirheumatic Agents therapeutic use
CD4 Antigens immunology
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Graft Rejection immunology
HLA-D Antigens immunology
Histocompatibility Antigens Class I immunology
Humans
Kidney Transplantation pathology
Antibodies, Monoclonal therapeutic use
Antibodies, Neoplasm therapeutic use
Antibody Formation immunology
Creatinine blood
HLA Antigens immunology
Immunosuppressive Agents therapeutic use
Kidney Transplantation immunology
Sirolimus therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 78
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 15385814
- Full Text :
- https://doi.org/10.1097/01.tp.0000134398.86243.81