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Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis.
- Source :
-
Shock (Augusta, Ga.) [Shock] 2004 Oct; Vol. 22 (4), pp. 309-13. - Publication Year :
- 2004
-
Abstract
- Macrophage migration inhibitory factor (MIF) is a cytokine playing a critical role in the pathophysiology of experimental sepsis. The purpose of this study was to determine the levels of MIF and to compare those to interleukin-6 (IL-6) levels in predicting mortality among critically ill patients with sepsis. The levels of MIF and IL-6 were measured in 25 patients with septic shock, 17 patients with sepsis, and 11 healthy volunteers. The median plasma concentrations of MIF and IL-6 were significantly higher in patients with septic shock and in patients with sepsis than in healthy controls. MIF levels were significantly different between survivors and nonsurvivors, as were IL-6 levels. Discriminatory power in predicting mortality, as assessed by the areas under receiver operating characteristic curves (AUROC), was 0.793 for MIF and 0.680 for IL-6. Finally, high plasma levels of MIF (> 1100 pg/mL) had a sensitivity of 100% and a specificity of 64% to identify the patients who eventually would evolve to a fatal outcome. Thus, our data suggest that an elevated MIF level in recently diagnosed septic patients appears to be an early indicator of poor outcome and a potential entry criterion for future studies with therapeutic intervention aiming at MIF neutralization.
- Subjects :
- APACHE
Adult
Aged
Area Under Curve
Biomarkers blood
Brazil epidemiology
Discriminant Analysis
Female
Humans
Intensive Care Units
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Interleukin-6 blood
Macrophage Migration-Inhibitory Factors blood
Shock, Septic immunology
Shock, Septic mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1073-2322
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Shock (Augusta, Ga.)
- Publication Type :
- Academic Journal
- Accession number :
- 15377884
- Full Text :
- https://doi.org/10.1097/01.shk.0000140305.01641.c8