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UV photolysis of 3-nitrotyrosine generates highly oxidizing species: a potential source of photooxidative stress.
- Source :
-
Chemical research in toxicology [Chem Res Toxicol] 2004 Sep; Vol. 17 (9), pp. 1227-35. - Publication Year :
- 2004
-
Abstract
- Laser flash photolysis at 266 nm of 3-nitrotyrosine and N-acetyl-3-nitrotyrosine ethyl ester generates an oxidizing species, which shows all of the characteristics of a hydroxyl radical. This species reacts with Br(-) to yield Br(2).-, via an intermediate, that is kinetically identified as HOBr.-. Moreover, the formation of Br(2).- can be suppressed by methanol; competition kinetics yield relative rate constants for the reaction of the reactive species with Br(-) and methanol that are similar to those for the hydroxyl radical. Parallel time-resolved UV/vis spectroscopy suggests the formation of phenoxyl radicals, consistent with the formation of hydroxyl radicals. Laser flash photolysis at 355 nm also generates reactive intermediates that oxidize Br(-) to Br(2).- but appear not to be hydroxyl radicals.
Details
- Language :
- English
- ISSN :
- 0893-228X
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical research in toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 15377156
- Full Text :
- https://doi.org/10.1021/tx049862u