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Short latency afferent inhibition and facilitation in patients with writer's cramp.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2005 Feb; Vol. 20 (2), pp. 238-42. - Publication Year :
- 2005
-
Abstract
- Patients with writer's cramp (WC) show abnormalities of sensorimotor integration possibly contributing to their motor deficit. We studied sensorimotor integration by determining short-latency afferent inhibition (SAI) in 12 WC patients and 10 age-matched healthy controls. A conditioning electrical median nerve stimulus was followed 14 to 36 msec later by transcranial magnetic stimulation of the contralateral primary motor cortex, and motor evoked potentials (MEP) were recorded from the relaxed or contracting abductor pollicis brevis muscle (APB). SAI was normal in WC but during APB relaxation SAI was followed by abnormal MEP facilitation, which was absent during APB contraction and in the controls. These findings suggest that somatosensory short-latency inhibitory input into the primary motor cortex is normal in WC, whereas a later excitatory input, which very likely reflects the long-latency reflex II, is exaggerated.<br /> (Copyright 2004 Movement Disorder Society.)
- Subjects :
- Adult
Analysis of Variance
Case-Control Studies
Electric Stimulation methods
Electromyography methods
Evoked Potentials, Motor drug effects
Female
Functional Laterality
Humans
Magnetics
Male
Median Nerve physiology
Median Nerve radiation effects
Middle Aged
Motor Cortex radiation effects
Muscle, Skeletal innervation
Muscle, Skeletal physiopathology
Neural Inhibition radiation effects
Reaction Time radiation effects
Afferent Pathways physiopathology
Dystonic Disorders physiopathology
Evoked Potentials, Motor physiology
Motor Cortex physiopathology
Neural Inhibition physiology
Reaction Time physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 15368612
- Full Text :
- https://doi.org/10.1002/mds.20295