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Proteases in host cell invasion by the malaria parasite.
- Source :
-
Cellular microbiology [Cell Microbiol] 2004 Oct; Vol. 6 (10), pp. 893-903. - Publication Year :
- 2004
-
Abstract
- The life cycle of the malaria parasite contains three distinct invasive forms, or zoites. For at least two of these--the sporozoite and the blood-stage merozoite--invasion into their respective host cell requires the activity of parasite proteases. This review summarizes the evidence for this, discusses selected well-described proteolytic modifications linked to invasion, and describes recent progress towards identifying the proteases involved.
- Subjects :
- Animals
Antigens, Protozoan metabolism
Humans
Membrane Proteins metabolism
Merozoite Surface Protein 1 metabolism
Plasmodium cytology
Plasmodium growth & development
Malaria parasitology
Peptide Hydrolases metabolism
Plasmodium enzymology
Plasmodium pathogenicity
Protozoan Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1462-5814
- Volume :
- 6
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cellular microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 15339265
- Full Text :
- https://doi.org/10.1111/j.1462-5822.2004.00437.x