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The relative importance of cyclosporine exposure in heart, kidney or liver transplant recipients on maintenance therapy.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2004 Oct; Vol. 17 (9), pp. 495-504. Date of Electronic Publication: 2004 Aug 28. - Publication Year :
- 2004
-
Abstract
- We investigated the relationship between cyclosporine exposure and the presence of cyclosporine-related side effects and assessed the advantage of the cyclosporine concentration 2 h post-dose (C(2)) over pre-dose concentration (C(0)) monitoring. Cyclosporine area-under-the-concentration-time curves were measured during the absorption phase (AUC(0-4 h)) in 49 liver, 28 heart and 26 kidney transplant recipients (time since transplantation >6 years) with or without cyclosporine-related side effects on maintenance therapy. The cyclosporine C(0) correlated well with AUC(0-4) (r=0.77), whereas C(2) levels correlated strongly with AUC(0-4) (r=0.92). Although we observed a trend towards higher CsA concentrations in transplant recipients with side effects than in patients without CsA toxicity, the large majority of those differences were not statistically significant. Thus, as cyclosporine exposure was not clearly related to the presence of side effects, and C(0) correlated fairly with AUC(0-4), the advantage of monitoring cyclosporine treatment using C(2) rather than C(0), may be limited for patients on cyclosporine maintenance therapy.
- Subjects :
- Adult
Cyclosporine adverse effects
Cyclosporine blood
Cyclosporine pharmacokinetics
Female
Humans
Immunosuppressive Agents adverse effects
Immunosuppressive Agents blood
Immunosuppressive Agents pharmacokinetics
Male
Middle Aged
Osmolar Concentration
Time Factors
Cyclosporine therapeutic use
Heart Transplantation immunology
Immunosuppressive Agents therapeutic use
Kidney Transplantation immunology
Liver Transplantation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0934-0874
- Volume :
- 17
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 15338117
- Full Text :
- https://doi.org/10.1007/s00147-004-0733-4