A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.

Authors :: Rücker E
Münch J
Wildum S
Brenner M
Eisemann J
Margolis L
Kirchhoff F
Source :: Journal of virology [J Virol] 2004 Sep; Vol. 78 (18), pp. 10197-201.
Publication Year :: 2004
Abstract: We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-rich region does not significantly affect the functional activity of Nef or HIV-1 infectivity or replication.<br /> (Copyright 2004 American Society for Microbiology)

Subjects :: Amino Acid Substitution
Gene Products, nef chemistry
Gene Products, nef physiology
Genes, nef
Genetic Variation
HIV-1 pathogenicity
HIV-1 physiology
HeLa Cells
Humans
Jurkat Cells
Mutagenesis, Site-Directed
Proline chemistry
Virulence genetics
Virus Replication genetics
nef Gene Products, Human Immunodeficiency Virus
Gene Products, nef genetics
HIV-1 genetics

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