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Expression of SIBLINGs and their partner MMPs in salivary glands.
- Source :
-
Journal of dental research [J Dent Res] 2004 Sep; Vol. 83 (9), pp. 664-70. - Publication Year :
- 2004
-
Abstract
- Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SIBLING-MMP activation pathway in vivo by showing that these 3 SIBLINGs and their known MMP partners are co-expressed in normal adult tissue. BSP, OPN, and DMP1 were invariably co-expressed with their partner MMPs in salivary glands of humans and mice. The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands. Expression of all SIBLINGs in this normal, non-mineralizing epithelial tissue suggests that they serve at least one function in vivo other than directly promoting matrix mineralization--a function we hypothesize involves local activation of MMPs.
- Subjects :
- Adult
Animals
Antibodies, Monoclonal
Cell Adhesion
Glycoproteins analysis
Humans
Immunoenzyme Techniques
Integrin-Binding Sialoprotein
Matrix Metalloproteinase 2 analysis
Matrix Metalloproteinase 3 analysis
Matrix Metalloproteinase 9 analysis
Mice
Osteopontin
Protein Precursors analysis
Salivary Ducts cytology
Salivary Ducts enzymology
Salivary Ducts metabolism
Salivary Glands cytology
Salivary Glands enzymology
Transcription Factors
Extracellular Matrix Proteins analysis
Matrix Metalloproteinases analysis
Phosphoproteins analysis
Proteins analysis
Salivary Glands metabolism
Sialoglycoproteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-0345
- Volume :
- 83
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 15329369
- Full Text :
- https://doi.org/10.1177/154405910408300902