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Triterpenoids. Part 21: Oleanolic acid azaderivatives as percutaneous transport promoters.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Sep 20; Vol. 14 (18), pp. 4723-6. - Publication Year :
- 2004
-
Abstract
- Some new oleanolic acid derivatives with lactame and thiolactame structures in the A- or C-ring were prepared and tested as percutaneous transport promoters in vitro. Their activity was comparable with activity of N-dodecylcaprolactame (Azone). A-Thiolactame derivative of methyl oleanolate (13) was the most effective compound.
- Subjects :
- Adjuvants, Pharmaceutic chemical synthesis
Administration, Cutaneous
Aza Compounds chemical synthesis
Biological Transport, Active
Humans
In Vitro Techniques
Lactams chemical synthesis
Permeability
Progesterone chemistry
Structure-Activity Relationship
Triterpenes chemical synthesis
Adjuvants, Pharmaceutic chemistry
Aza Compounds chemistry
Lactams chemistry
Membranes, Artificial
Skin Absorption
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15324895
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.06.087