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Volume adjustment of lung density by computed tomography scans in patients with emphysema.
- Source :
-
Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2004 Jul; Vol. 45 (4), pp. 417-23. - Publication Year :
- 2004
-
Abstract
- Purpose: To determine how to adjust lung density measurements for the volume of the lung calculated from computed tomography (CT) scans in patients with emphysema.<br />Material and Methods: Fifty patients with emphysema underwent 3 CT scans at 2-week intervals. The scans were analyzed with a software package that detected the lung in contiguous images and subsequently generated a histogram of the pixel attenuation values. The total lung volume (TLV), lung weight, percentile density (PD), and relative area of emphysema (RA) were calculated from this histogram. RA and PD are commonly applied measures of pulmonary emphysema derived from CT scans. These parameters are markedly influenced by changes in the level of inspiration. The variability of lung density due to within-subject variation in TLV was explored by plotting TLV against PD and RA.<br />Results: The coefficients for volume adjustment for PD were relatively stable over a wide range from the 10th to the 80th percentile, whereas for RA the coefficients showed large variability especially in the lower range, which is the most relevant for quantitation of pulmonary emphysema.<br />Conclusion: Volume adjustment is mandatory in repeated CT densitometry and is more robust for PD than for RA. Therefore, PD seems more suitable for monitoring the progression of emphysema.
- Subjects :
- Absorptiometry, Photon methods
Aged
Airway Obstruction physiopathology
Female
Follow-Up Studies
Forced Expiratory Volume physiology
Humans
Image Processing, Computer-Assisted methods
Inhalation physiology
Lung physiopathology
Male
Middle Aged
Pulmonary Diffusing Capacity physiology
Pulmonary Emphysema physiopathology
Smoking adverse effects
Total Lung Capacity physiology
Vital Capacity physiology
alpha 1-Antitrypsin Deficiency complications
Lung diagnostic imaging
Lung Volume Measurements methods
Pulmonary Emphysema diagnostic imaging
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 0284-1851
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta radiologica (Stockholm, Sweden : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 15323394
- Full Text :
- https://doi.org/10.1080/02841850410005525