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Oral Candida flora from Brazilian human immunodeficiency virus-infected patients in the highly active antiretroviral therapy era.
- Source :
-
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2004 Jun; Vol. 99 (4), pp. 425-31. Date of Electronic Publication: 2004 Aug 13. - Publication Year :
- 2004
-
Abstract
- One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90% of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8% were identified as Candida albicans and 42.1% as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5%), C. lusitaniae (5.2%), C. tropicalis (4.6%), C. parapsilosis (4.6%), C. glabrata (2.8%), C. kefyr (1.7%), C. guilliermondii (1.7%), C. intermedia (1.1%), C. norvegensis (0.5%), and Rhodotorula rubra (1.7%). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 micro g/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.
- Subjects :
- Brazil
Candida drug effects
Candida isolation & purification
Case-Control Studies
Female
HIV Infections microbiology
Humans
Male
Microbial Sensitivity Tests
AIDS-Related Opportunistic Infections microbiology
Antifungal Agents pharmacology
Antiretroviral Therapy, Highly Active
Candida classification
Candidiasis, Oral microbiology
HIV Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0074-0276
- Volume :
- 99
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- 15322634
- Full Text :
- https://doi.org/10.1590/s0074-02762004000400014