Back to Search
Start Over
Effects of captopril treatment on left ventricular remodeling and function after anterior myocardial infarction: comparison with digitalis.
- Source :
-
Journal of the American College of Cardiology [J Am Coll Cardiol] 1992 Mar 15; Vol. 19 (4), pp. 858-63. - Publication Year :
- 1992
-
Abstract
- The effects of captopril and digoxin treatment on left ventricular remodeling and function after anterior myocardial infarction were evaluated in a randomized unblinded trial. Fifty-two patients with a first transmural anterior myocardial infarction and a radionuclide left ventricular ejection fraction less than 40% were randomly assigned to treatment with captopril (Group A) or digoxin (Group B). The two groups had similar baseline hemodynamic, coronary angiographic, echocardiographic and radionuclide angiographic variables. Among the 40 patients (20 in each group) who were followed up for 1 year, echocardiographic end-diastolic and end-systolic volumes were unmodified in Group A and global wall motion index was improved (p less than 0.01); in Group B, end-diastolic and end-systolic volumes increased (p less than 0.001 for both) and global wall motion index was unchanged. Rest radionuclide ejection fraction increased significantly in both groups (p less than 0.001, Group A; p less than 0.005, Group B). A comparison of the changes in the considered variables between the two groups after 1 year of treatment showed a difference in end-diastolic (p less than 0.005) end-systolic volumes (p less than 0.001) and global wall motion index (p less than 0.005) without differences in radionuclide ejection fraction, which improved to a similar degree in both groups. The results of this study suggest that captopril therapy, started 7 to 10 days after symptom onset in patients with anterior myocardial infarction and an ejection fraction less than 40%, improves both left ventricular remodeling and function and prevents left ventricular enlargement and in these patients performs better than digitalis.
- Subjects :
- Cardiomegaly prevention & control
Echocardiography
Female
Follow-Up Studies
Gated Blood-Pool Imaging
Humans
Male
Middle Aged
Myocardial Infarction diagnosis
Myocardial Infarction epidemiology
Stroke Volume drug effects
Time Factors
Captopril therapeutic use
Digoxin therapeutic use
Myocardial Infarction drug therapy
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0735-1097
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of the American College of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 1531993
- Full Text :
- https://doi.org/10.1016/0735-1097(92)90532-r