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Imatinib and pegylated human recombinant interferon-alpha2b in early chronic-phase chronic myeloid leukemia.
- Source :
-
Blood [Blood] 2004 Dec 15; Vol. 104 (13), pp. 4245-51. Date of Electronic Publication: 2004 Aug 19. - Publication Year :
- 2004
-
Abstract
- Since interferon-alpha and imatinib (IM; STI571, Glivec, Gleevec) are effective for the treatment of chronic myeloid leukemia (CML), and their mechanisms of action are different, we designed an exploratory study investigating the effects of a standard IM dose (400 mg/d) and a variable pegylated interferon-alpha (PegIFN) dose (50 microg/wk, 100 microg/wk, and 150 microg/wk). The criteria for dose adjustment were designed so as to ensure the delivery of the IM dose and to protect life quality. There were 76 patients with previously untreated Philadelphia (Ph)-positive CML enrolled in the study. There were 3 patients who discontinued IM and 45 patients who discontinued PegIFN. The severity of adverse events increased with increasing PegIFN dose. The IM dose could be administered to the patients who were assigned to receive 50 microg/wk or 100 microg/wk PegIFN but not to those who were assigned to receive 150 microg/wk. The median administered dose of PegIFN ranged between 32 microg/wk and 36 microg/wk. The cytogenetic response was 70% complete (Ph-neg 100%) and 83% major (Ph-neg > 65%). The BCR/ABL transcript was reduced by at least 3 logs in 68% of complete cytogenetic responders. These data of toxicity, compliance, and efficacy may assist in the design and preparation of prospective studies.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols toxicity
Benzamides
Dose-Response Relationship, Drug
Female
Humans
Imatinib Mesylate
Interferon alpha-2
Interferon-alpha toxicity
Male
Middle Aged
Piperazines toxicity
Pyrimidines toxicity
Recombinant Proteins
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Interferon-alpha administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Piperazines administration & dosage
Pyrimidines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 104
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 15319292
- Full Text :
- https://doi.org/10.1182/blood-2004-03-0826