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Modulation of hematopoietic stem cell homing and engraftment by CD26.
- Source :
-
Science (New York, N.Y.) [Science] 2004 Aug 13; Vol. 305 (5686), pp. 1000-3. - Publication Year :
- 2004
-
Abstract
- Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.
- Subjects :
- Animals
Benzylamines
Cell Cycle
Cell Movement
Cell Survival
Chemokine CXCL12
Chemokines, CXC pharmacology
Chemotaxis drug effects
Cyclams
Female
Heterocyclic Compounds pharmacology
Mice
Mice, Inbred C57BL
Oligopeptides pharmacology
Receptors, CXCR4 antagonists & inhibitors
Dipeptidyl Peptidase 4 physiology
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 305
- Issue :
- 5686
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 15310902
- Full Text :
- https://doi.org/10.1126/science.1097071