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[Experimental study of the treatment of carcinomatous peritonitis in gastric cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1992 Aug; Vol. 19 (10 Suppl), pp. 1720-3. - Publication Year :
- 1992
-
Abstract
- To prevent dissemination to the peritoneum following surgery for gastric cancer, examinations were performed with mouse ascites cancer models and the objective of enhancing the combined effect of MMC, CDDP and 5-FU. Pharmaceutical dosage was set at approximately 30% of the increased life span (ILS) for Meth-A. The dosage was 0.2 mg/kg for MMC, 1 mg/kg for CDDP and 37.5 mg/kg for 5-FU. Results indicated that simultaneous combination of 0.2 mg/kg of MMC and 1 mg/kg of CDDP extended life significantly more than individual administration, and clinical application of this combination was considered to be possible. In contrast, simultaneous combination of 1 mg/kg of CDDP and 37.5 mg/kg of 5-FU had no clear life-extending effect compared to individual administration of each. Some biochemical modulation of the administration method was thus considered necessary.
- Subjects :
- Animals
Cisplatin administration & dosage
Fluorouracil administration & dosage
Infusions, Parenteral
Male
Mice
Mitomycin administration & dosage
Peritonitis prevention & control
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Peritonitis drug therapy
Stomach Neoplasms pathology
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 19
- Issue :
- 10 Suppl
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 1530340