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McArdle's disease diagnosed following statin-induced myositis.
- Source :
-
Annals of clinical biochemistry [Ann Clin Biochem] 2004 Jul; Vol. 41 (Pt 4), pp. 338-40. - Publication Year :
- 2004
-
Abstract
- We describe the case of a 69-year-old man with a history of muscular symptoms dating back to his childhood; McArdle's disease (glycogen-storage disease V) was diagnosed following an episode of myositis in which a statin and physical exertion appear to have been precipitating factors. This case demonstrates that the ischaemic lactate-ammonia test still has a place in screening patients with symptoms suggestive of McArdle's disease and emphasizes the importance of carrying out glycogen phosphorylase histochemistry on the skeletal muscle biopsy to confirm the diagnosis. In patients who develop a raised plasma creatine kinase level or muscular symptoms during lipid-lowering therapy, the clinician should be alert to the possibility of an underlying myopathy.
- Subjects :
- Aged
Ammonia blood
Anticholesteremic Agents adverse effects
Creatine Kinase blood
Glycogen Storage Disease Type V metabolism
Humans
Lactic Acid blood
Male
Muscle, Skeletal metabolism
Myositis metabolism
Physical Exertion
Glycogen Storage Disease Type V diagnosis
Myositis chemically induced
Simvastatin adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0004-5632
- Volume :
- 41
- Issue :
- Pt 4
- Database :
- MEDLINE
- Journal :
- Annals of clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15298748
- Full Text :
- https://doi.org/10.1258/0004563041201554