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Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.
- Source :
-
Journal of virology [J Virol] 2004 Aug; Vol. 78 (16), pp. 8844-51. - Publication Year :
- 2004
-
Abstract
- The immune correlates of protection in human immunodeficiency virus type 1 (HIV-1) infection remain poorly defined, particularly the contribution of CD4(+) T cells. Here we explore the effector functions of HIV-1-specific CD4(+) T cells. We demonstrate HIV-1 p24-specific CD4(+)-T-cell cytolytic activity in peripheral blood mononuclear cells directly ex vivo and after enrichment by antigen-specific stimulation. We further show that in a rare long-term nonprogressor, both an HIV-1-specific CD4(+)-T-cell clone and CD4(+) T cells directly ex vivo exert potent suppression of HIV-1 replication. Suppression of viral replication was dependent on cell-cell contact between the effector CD4(+) T cells and the target cells. While the antiviral effector activity of CD8(+) T cells has been well documented, these results strongly suggest that HIV-1-specific CD4(+) T cells are capable of directly contributing to antiviral immunity.
- Subjects :
- CD4-Positive T-Lymphocytes virology
Cytotoxicity, Immunologic
HIV Core Protein p24 immunology
Humans
Leukocytes, Mononuclear immunology
Virus Replication immunology
CD4-Positive T-Lymphocytes immunology
HIV-1 immunology
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 78
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 15280492
- Full Text :
- https://doi.org/10.1128/JVI.78.16.8844-8851.2004