Emergence in Italy of a Neisseria meningitidis clone with decreased susceptibility to penicillin.

Authors :: Stefanelli P
Fazio C
Neri A
Sofia T
Mastrantonio P
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2004 Aug; Vol. 48 (8), pp. 3103-6.
Publication Year :: 2004
Abstract: A rise in invasive diseases due to Neisseria meningitidis C:2b:P1.5 with decreased penicillin susceptibility occurred in Italy during the last 2 years. Real-time PCR identified the Peni phenotype, and the penA sequence revealed the mosaicism of the gene. Molecular analyses assigned the isolates to a single emergent clone of the hypervirulent A4 cluster.

Subjects :: DNA Fingerprinting
DNA, Bacterial genetics
Electrophoresis, Gel, Pulsed-Field
Humans
Italy epidemiology
Meningitis, Meningococcal epidemiology
Mosaicism genetics
Phenotype
Reverse Transcriptase Polymerase Chain Reaction
Meningitis, Meningococcal microbiology
Neisseria meningitidis drug effects
Neisseria meningitidis genetics
Penicillin Resistance genetics

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