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Differentiation of the midbrain dopaminergic pathways during mouse development.
- Source :
-
The Journal of comparative neurology [J Comp Neurol] 2004 Aug 23; Vol. 476 (3), pp. 301-11. - Publication Year :
- 2004
-
Abstract
- Dopaminergic (DA) neurons in the substantia nigra (SN) and ventral tegmental area (VTA) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. Disruptions in this system have been implicated in Parkinson's disease, drug addiction, schizophrenia, and attention deficit hyperactivity disorder. However, progress in our understanding has been hindered by a lack of knowledge of how these pathways develop. In this study, different retrograde tracers, placed into the dorsolateral caudate/putamen and the nucleus accumbens, were used to analyze the development of the dopaminergic pathways. In embryonic day 15 mouse embryos, both SN and VTA neurons, as well as their fibers, were doubly labeled by striatal injections into the dorsolateral and ventromedial striatum. However, by birth, the SN DA neurons were labeled exclusively by DiA placed in the dorsolateral striatum, and the VTA DA neurons were labeled only by DiI injected into the ventromedial striatum. These data suggest that initial projections from midbrain DA neurons target nonspecifically to both the dorsolateral striatum and the nucleus accumbens. Later during development, the separate mesostriatal and mesolimbic pathways differentiate through the selective elimination of mistargeted collaterals.
- Subjects :
- Aging pathology
Animals
Axonal Transport
Caudate Nucleus cytology
Caudate Nucleus growth & development
Caudate Nucleus metabolism
Cell Differentiation
Dopamine metabolism
Female
Fluorescent Dyes
Mesencephalon anatomy & histology
Mesencephalon growth & development
Mesencephalon metabolism
Mice
Mice, Inbred Strains
Neostriatum cytology
Neostriatum metabolism
Neural Pathways growth & development
Neural Pathways metabolism
Neurons metabolism
Pregnancy
Putamen anatomy & histology
Putamen growth & development
Putamen metabolism
Substantia Nigra cytology
Substantia Nigra growth & development
Substantia Nigra metabolism
Ventral Tegmental Area cytology
Ventral Tegmental Area metabolism
Aging physiology
Neostriatum growth & development
Neural Pathways cytology
Neurons cytology
Ventral Tegmental Area growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9967
- Volume :
- 476
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of comparative neurology
- Publication Type :
- Academic Journal
- Accession number :
- 15269972
- Full Text :
- https://doi.org/10.1002/cne.20230