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Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis/HTLV-I-associated myelopathy.
- Source :
-
Journal of neurology [J Neurol] 2004 Jul; Vol. 251 (7), pp. 877-81. - Publication Year :
- 2004
-
Abstract
- Tropical spastic paraparesis/ HTLV-I-associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV-I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV-I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV-I infection. We conclude that HTLV-I infection should be investigated in patients with PN of unknown origin.
- Subjects :
- Adult
Aged
Biopsy
Demyelinating Diseases pathology
Demyelinating Diseases physiopathology
Diagnosis, Differential
Electrodiagnosis
Female
HTLV-I Infections immunology
HTLV-I Infections physiopathology
Humans
Inflammation pathology
Inflammation physiopathology
Male
Middle Aged
Peripheral Nerves physiopathology
Peripheral Nervous System Diseases immunology
Peripheral Nervous System Diseases virology
Serologic Tests
Sural Nerve pathology
Sural Nerve physiopathology
Wallerian Degeneration pathology
Wallerian Degeneration physiopathology
HTLV-I Infections complications
Human T-lymphotropic virus 1 immunology
Paraparesis, Tropical Spastic diagnosis
Peripheral Nerves pathology
Peripheral Nervous System Diseases diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0340-5354
- Volume :
- 251
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 15258793
- Full Text :
- https://doi.org/10.1007/s00415-004-0455-7