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c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx.

c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx.

Authors :
Ozdek A
Sarac S
Akyol MU
Sungur A
Yilmaz T
Source :
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2004 Jul; Vol. 131 (1), pp. 77-83.
Publication Year :
2004

Abstract

Objectives: To evaluate the expression and prognostic significance of c-myc and bcl-2 oncogenes in squamous cell carcinoma (SCC) of the supraglottic larynx. Study design A retrospective cohort study of 61 patients who underwent surgery for SCC of the supraglottic larynx. Gender, age, TNM status, operative procedure, recurrences, and disease-free survival periods were recorded.<br />Methods: Hematoxylin and eosin-stained sections were reexamined for grade, invasion of tumor margins, lymphovascular invasion, lymphocyte infiltration, and perineural invasion. Immunohistochemical detection of c-myc and bcl-2 oncogenes was performed using monoclonal antibodies.<br />Results: No correlation was observed between either c-myc or bcl-2 and the clinical and histopathologic parameters. Survival analysis revealed no correlation of either c-myc (P = 0.88) or bcl-2 (P = 0.85) with the disease-free survival. c-myc expression was found to be significantly higher in bcl-2-positive patients (P = 0.001).<br />Conclusion: Neither c-myc nor bcl-2 had shown to be prognostic factor for laryngeal carcinoma in this present study. Correlation between c-myc and bcl-2 supports the experimental observations of cooperative action between these two genes in tumorigenesis.

Details

Language :
English
ISSN :
0194-5998
Volume :
131
Issue :
1
Database :
MEDLINE
Journal :
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Publication Type :
Academic Journal
Accession number :
15243561
Full Text :
https://doi.org/10.1016/j.otohns.2004.02.015