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Ocular presentation of primary central nervous system lymphoma: diagnosis and treatment.
- Source :
-
British journal of haematology [Br J Haematol] 2004 Jul; Vol. 126 (2), pp. 202-8. - Publication Year :
- 2004
-
Abstract
- Primary ocular lymphoma (POL), a lymphoma of the globe, is a restricted form of primary central nervous system lymphoma (PCNSL) that often progresses to the brain and meninges; frequently it is misdiagnosed until central nervous system (CNS) lymphoma develops. The optimal treatment has not yet been identified. We retrospectively reviewed the course and the treatment of POL in 31 patients. Seventeen patients were treated for isolated POL (group A) and 14 were treated only after CNS disease was diagnosed (group B). The treatment in both groups consisted of systemic chemotherapy, chemotherapy plus radiotherapy (RT) or RT alone. In group A, nine patients (53%) developed CNS progression and five (29%) had ocular recurrence. In group B, seven (50%) had CNS progression and three (21%) ocular relapse. To control for diagnostic lead time, median survival was calculated from initial ocular symptoms and was 60 months in group A and 35 months in group B (P < 0.05). Ocular lymphoma responds to a variety of therapies but treatment with chemotherapy and/or ocular radiotherapy (ORT) failed to prevent CNS progression. Patients whose ocular disease was identified and treated before CNS progression had a significantly improved survival.
- Subjects :
- Adult
Aged
Aged, 80 and over
Central Nervous System Neoplasms mortality
Central Nervous System Neoplasms radiotherapy
Disease Progression
Eye Neoplasms mortality
Eye Neoplasms radiotherapy
Female
Humans
Lymphoma, Non-Hodgkin mortality
Lymphoma, Non-Hodgkin radiotherapy
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Retrospective Studies
Survival Rate
Uveitis drug therapy
Uveitis radiotherapy
Vitreous Body
Central Nervous System Neoplasms drug therapy
Eye Neoplasms drug therapy
Lymphoma, Non-Hodgkin drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 126
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 15238140
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2004.05028.x